News

Tailored Surgical Approach Leads to Better Outcomes in Ovarian Cancer

(March 10, 2015) An algorithm developed at MD Anderson Cancer Center in Houston has dramatically increased complete resection rates in advanced ovarian cancer, giving patients the best possible chance of survival. The work was funded in part by an OCRF research grant to Anil Sood, MD. The results are... 

OCRF Research Finds New Therapeutic Strategy for Ovarian Cancer

Rugang Zhang, PhD (February 17, 2015) OCRF-funded researchers at The Wistar Institute have identified a new therapeutic target in clear cell ovarian cancer, paving the way for what could be the first effective targeted therapy of its kind for the disease. The findings were published online by the journal... 

New Tool Could Speed Development of Ovarian Cancer Drugs

(February 13, 2015) University of Chicago Medicine researchers, including OCRF grantee and Scientific Advisory Committee member Ernst Lengyel, MD, PhD, have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis.... 

Meet OCRF’s 2015 Grantees

(February 11, 2015) Ovarian Cancer Research Fund has announced that $6.1 million has been awarded in scientific research grants for ovarian cancer. This brings OCRF’s total investment in research and related educational and support initiatives to over $65 million. The twenty new OCRF research grants... 

SGI-110 is an Ovarian Cancer Chemosensitizer

Ken Nephew, PhD (February 4, 2014)  In research published last October in Clinical Cancer Research, a team of OCRF-funded investigators showed that a novel therapy can resentisize ovarian cancer to chemotherapy.  The work was led by Dr. Kenneth Nephew, who was funded through an OCRF Program Project... 

OCRF Research Identifies Six New Susceptibility Loci for Ovarian Cancer

(Feb. 3, 2015) An international study using data from the OCRF-funded Ovarian Cancer Association Consortium has found six new gene regions which increase a woman’s risk of ovarian cancer.  The findings were published this month in Nature Communications. Previous studies have identified 12 epithelial... 

Population Study Shows Salpingectomy Decreases Risk of Ovarian Cancer

(Feb. 2, 2015) Recent studies have suggested that ovarian cancer predominantly arises within the fallopian tubes or the uterus. A group of Swedish researchers hypothesized that surgical removal of the fallopian tubes (salpingectomy) is associated with a reduced risk for ovarian cancer. In the study,... 

OCRF Research Pinpoints Two Genes that Trigger Ovarian Cancer

(January 28, 2015) OCRF grantee Ron Chandler, PhD developed a mouse model of clear cell ovarian cancer and found a potential route to better treatments and much-needed diagnostic screens. Dr. Chandler spearheaded a team of researchers at University of North Carolina that developed a mouse model of clear... 

Veliparib Trial Fails to Improve Outcomes in Ovarian Cancer

(January 26, 2015) Use of the PARP inhibitor veliparib in combination with oral cyclophosphamide did not result in an improvement in response rate or median progression-free survival compared with treatment with cyclophosphamide alone, according to a phase II study evaluating patients with high-grade... 

BRCA1/2 Mutations and 10 year Survival in Ovarian Cancer

(January 22, 2015) In a study published in Clinical Cancer Research, researchers analyzed the effect of germline mutations in BRCA1 and BRCA2 on mortality in ovarian cancer patients up to ten years after diagnosis. The researchers found that BRCA1/2 mutations are associated with better short-term survival,...