Research News

Use of Intensive Medical Services for Ovarian Cancer Patients at End of Life Increases Despite Rise in Use of Hospice

There have been widespread efforts to improve the quality of life of terminally ill patients. As more patients choose to spend their final days and weeks in hospice care rather than a hospital, the hope is the use of intensive and costly hospital services would decline. A large new study by Dana-Farber... 

Telomere Length and Mortality Following An Ovarian Cancer Diagnosis

Telomeres are essential for the maintenance of chromosomal integrity. Telomere shortening leads to genomic instability, which is hypothesized to play a role in cancer development and prognosis. New data published in Cancer Epidemiology, Biomarkers & Prevention, provide preliminary evidence that telomere... 

Detection of Gene Mutations in Tampons of Patients With High-Grade Serous Ovarian Cancer

(October 14, 2014) In a pilot study published in the journal Obstetrics & Gynecology, researchers detected DNA derived from tumor cells in the vaginas of 60% of patients with ovarian cancer with intact fallopian tubes. With further development, this approach may hold promise for the early detection... 

Ovarian Cancer Oncogene Found in ‘Junk DNA’

(October 6, 2014) A research team based at the University of Pennsylvania mined junk DNA sequences to identify a non-protein-coding RNA whose expression is linked to ovarian cancer.  The study, which was published in Cancer Cell, was supported in part by an OCRF research grant to Lin Zhang, MD. The... 

SGO Perspectives on Endpoints for Studies of Ovarian Cancer

(Sept. 29, 2014) In a perspective piece for the website MedPage Today, representatives from the Society of Gynecologic Oncology discuss clinical endpoints appropriate for studies addressing the “unique characteristics” of ovarian cancer and progress toward improving outcomes for women affected... 

Maintenance Pazopanib in Ovarian Cancer: No Survival Benefit, High Rate of Complications

(Sept. 25, 2014) Maintenance therapy with the oral agent pazopanib improved progression free survival (PFS) by a median of 5.6 months in patients with advanced ovarian cancer but did not impact overall survival, according to the results of a phase III randomized trial reported in the Journal of Clinical... 

OCRF Research Finds Metastasis Promoted by Mesothelial Cells

Ernst Lengyel, MD, PhD A new study in the Journal of Clinical Investigation indicates that mesothelial cells actively promote the spread of ovarian cancer. Using a three dimensional culture model of ovarian cancer metastasis, OCRF grantee and Scientific Advisory Committee Member Ernst Lengyel, MD, PhD,... 

Ovarian Cancer Dream Team Call for Ideas Now Open

The American Association for Cancer Research is now accepting submissions of ideas for the new Stand Up To Cancer Ovarian Cancer Translational Research Dream Team Grant that will offer up to $6 million in research funding, which includes $3 million provided by the leading funder, OCRF. The Stand Up... 

New Study Shows No Association between Powder Use and Ovarian Cancer

(September 12, 2014) A new study published in the Journal of the National Cancer Institute this month suggests that use of perineal powder does not influence ovarian cancer risk. In the past, some studies have suggested that there is an increased risk of ovarian cancer among talc users.  In this new... 

New Stand Up To Cancer Ovarian Cancer Dream Team Announced

Ovarian Cancer Community Joins Forces to Fight Deadliest Gynecologic Cancer A groundbreaking collaboration among three national ovarian cancer organizations was announced during the Stand Up to Cancer telecast on Friday evening, September 5th. Ovarian Cancer Research Fund (OCRF), Ovarian Cancer National...