Research News

Bevacizumab with Chemo Improves Survival in Ovarian Cancer with Poor Prognosis

(July 1, 2015) When bevacizumab was added to standard chemotherapy, the patients with a poor prognosis of ovarian cancer had an overall survival benefit, according to the ICON7 study published online this week in journal The Lancet Oncology. The study enrolled 1,528 women with newly diagnosed ovarian... 

OCRF Researchers Find Clues on Mucinous Ovarian Cancer Origins

(June 19, 2015) In a recent study, funded in part by OCRF grants to Dr. Simon Gayther and Dr. Andrew Berchuck, researchers have made important breakthroughs toward understanding the risk and growth of a certain kind of ovarian cancer, known as mucinous ovarian carcinoma, or MOC. The international study... 

Investigators Discover How Ovarian Cancer Halts Body’s Natural Defense Against Tumor

(June 18, 2015) A team of researchers, including OCRF grantees Juan Cubillos-Ruiz, PhD, and Alfredo Perales-Puchalt, MD, have discovered how ovarian cancer shuts down immune system cells that would otherwise act as a first line of defense against the deadly tumor. The findings are published in the June... 

Ovarian Cancers Sensitive to Chemo Identified by Gene Mutations

(June 17, 2015) Researchers at MD Anderson Cancer Center in Houston have identified a new class of gene mutations that may contribute to outcomes in the treatment of ovarian cancer. Research on the gene family known as ADAMTS could open up a new genetic avenue for the design of ovarian cancer therapies.... 

Ovarian Cancer News from ASCO

(June 5, 2015) The Society of Gynecologic Oncology has posted three short videos on YouTube that highlight some of the ovarian cancer research findings presented at the American Society of Clinical Oncology annual meeting last week. Click here to watch the videos, which highlight the results of a number... 

Whole-Genome Characterization of Chemoresistant Ovarian Cancer

(May 28, 2015) In an effort to study treatment options for high-grade serous ovarian cancer, scientists from the University of Queensland and Sydney’s Millennium Institute collected DNA from 92 patients to find out what makes those cells so resistant to chemotherapy.  OCRF Scientific Advisory Committee... 

Chemo Before Surgery Leads to Better Outcomes

(May 28, 2015) A recent study performed in the UK and New Zealand revealed that having chemotherapy treatments before and after surgery is associated with a higher quality of life when compared to those who undergo surgery before chemotherapy. The study, which included 550 women with Stage III or IV... 

New Screening Approach Shows Promise

(May 5, 2015) Data from a large clinical trial shows that a personalized method for interpreting blood tests identifies more ovarian cancer cases than a generalized approach. The results from the study will be published in the Journal of Clinical Oncology. Using an algorithm to analyze changes in the... 

Oophorectomy Increases Breast Cancer Survival in BRCA1 Mutation Carriers

(April 29, 2015) A study published in JAMA Oncology last Saturday concluded that an oophorectomy, the surgery to remove ones ovaries, has a substantial impact on survival rates for those diagnosed with stage I or II breast cancer who also tested positive for the BRCA1 mutation. Involved in the study... 

New Recommendations for Ovarian Cancer Prevention

(April 16, 2015) The Society of Gynecologic Oncology has published recommendations for prevention of ovarian cancer in Cancer.  Strategies include oral contraceptive use and tubal sterilization, as well as genetic counseling and testing for women from high-risk families. Read the abstract here.  MORE