Research News

OCRF Research Shows How Ovarian Tumors Elude Immune System

Greg Motz, PhD (May 6, 2014) Tumors use numerous mechanisms to escape detection and killing by the immune system. Results from OCRF-funded research, reported May 4, 2014 in the prestigious journal Nature Medicine, show that ovarian cancer cells (and others) establish a protective barrier that prevents... 

Imaging Predicts Response in Ovarian Cancer

(April 30, 2014) A positive pretreatment imaging test more than doubled the likelihood of disease control in platinum-resistant advanced ovarian cancer treated with the folate receptor-targeted drug vintafolide (trade name Vynfinit), results of a small phase II study showed. The research was reported in... 

News from AACR: Irregular Menses Linked to High Risk of Ovarian Cancer

(April 15, 2014) Prolonged (>35 days), infrequent, or anovulatory menstrual cycles was associated with as much as a two-fold increase in ovarian cancer and more than a three-fold increase in the risk of fatal ovarian cancer, according to a 50-year, prospective follow-up in 14,403 women. The findings... 

Physical Activity Associated with Lower Risk of Ovarian Cancer Mortality

(April 8, 2014) A team of researchers have found that vigorous physical activity prior to ovarian cancer diagnosis was associated with a lower risk of ovarian cancer mortality.  The findings were published in Gynecologic Oncology. There is limited knowledge of the association of modifiable lifestyle... 

OCRF Research Identifies Fusion Gene Common in Ovarian Cancer

(April 7, 2014) A group of OCRF-funded researchers at Baylor College of Medicine have found a “fusion gene” that is present in 20% of high grade serous ovarian cancer patients.  The finding, which was published in PLOS Genetics, was supported in part by OCRF grants to Martin Matzuk, MD,... 

2015 OCRF Requests for Proposals Now Available

(April 1, 2014)  Ovarian Cancer Research Fund is now accepting Letters of Intent for its three research grant programs.  Letters of Intent must be submitted by May 6, 2014 at 5:00pm ET. Click here for complete application information.  MORE

Gene Mutation Causes Rare Ovarian Cancer

(March 25, 2014) In what is being hailed as a major discovery, findings published this week indicate that researchers have discovered a gene mutation that causes Small Cell Carcinoma of the Ovary, Hypercalcemic type. OCRF Scientific Advisory Committee member, and former grantee, Douglas A. Levine, MD,... 

SGO Position Statement on Genetic Testing for Gynecologic Cancer

(March 20, 2014) The Society for Gynecologic Oncology has released a statement on the use of genetic testing for women with gynecologic cancer. The statement says that women diagnosed with epithelial ovarian, fallopian tube, and peritoneal cancers should receive genetic counseling and consider genetic... 

Avastin and Chemo for Platinum-Resistant Ovarian Cancer Increases Progression Free Survival

(March 20, 2014) A group of French researchers conducted a randomized, phase III trial (called AURELIA) combining bevacizumab (Avastin) with chemotherapy in platinum-resistant ovarian cancer.  The results of the trial, which enrolled 361 patients, were published in the Journal of Clinical Oncology. The... 

Weekly Carboplatin Plus Paclitaxel Improves Quality of Life

(March 14, 2014)  A large European clinical trial showed that carboplatin plus paclitaxel once a week (versus every three weeks) can be an effective front-line treatment for women with advanced ovarian cancer. The results of the study were published in the medical journal The Lancet. Carboplatin plus...