Research News

New Stand Up To Cancer Ovarian Cancer Dream Team Announced

Ovarian Cancer Community Joins Forces to Fight Deadliest Gynecologic Cancer A groundbreaking collaboration among three national ovarian cancer organizations was announced during the Stand Up to Cancer telecast on Friday evening, September 5th. Ovarian Cancer Research Fund (OCRF), Ovarian Cancer National... 

Statin Therapy and Improved Survival in Some Ovarian Cancer Patients

(September 2, 2014) New research by researchers at the University of Chicago, including OCRF grantee and Scientific Advisory Committee member Ernst Lengyel, MD, PhD, investigated whether statin use is associated with improved epithelial ovarian cancer (OvCa) survival.  The findings were published this... 

Dietary Fat Intake and Risk of Epithelial Ovarian Cancer

(August 27, 2014) Recent research published in Cancer Epidemiology suggests that there is “no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive epithelial ovarian cancer.” An international team of researchers... 

New Report Recommends Classifying Cancer by Genetic and Molecular Type

(August 21, 2014) A research network in the US proposes that cancer should be classified according to genetic and molecular features rather than by the type of tissue in which the tumor arises. While more work is needed to confirm and build on the findings, the scientists say such a system would be better... 

Drug Combination Impacts Outcomes in Ovarian Cancer Patients without BRCA Mutations

Ron Buckanovich, MD, PhD BRCA mutations in ovarian cancer are a double-edged sword.  While BRCA gene mutation carriers have a significantly higher risk of developing ovarian cancer, BRCA gene mutation in tumors is associated with a significant increase in patient survival.  Scientists believe that... 

Epigenetic Targeting of Ovarian Cancer Stem Cells

(July 29, 2014)   OCRF-funded research published earlier this month provides the first proof of principle that epigenomic strategies efficiently target ovarian cancer stem cells, which are key for treatment resistance and the major factor in therapy failures.  OCRF grantees Kenneth Nephew, PhD and... 

Most High Risk Women Aren’t Aware of Ovarian Cancer Risk

(July 28, 2014) Research published last week in Behavioral Medicine suggests that most high-risk women (>75%) do not know their risk for ovarian cancer. Women with a documented deleterious mutation in BRCA1 or BRCA2 are at substantially elevated risk for ovarian cancer. To understand what percentage... 

OCRF Research Sheds New Light on Ovarian Cancer Metastasis

(July 21, 2014) According to research funded in part by OCRF, circulating tumor cells spread ovarian cancer through the bloodstream, homing in on a sheath of abdominal fatty tissue where it can grow and metastasize to other organs. This new finding, supported in part by an OCRF Program Project Development... 

OCRF Research Shows ARID1A is Tumor Suppressor Gene

Bin Guan, PhD (July 8, 2014) Frequent mutations in the ARID1A gene have been previously discovered in ovarian endometrioid and clear-cell cancers.  Now research supported by OCRF has provided direct evidence that it is an authentic tumor suppressor gene using a mouse model.  OCRF Ann Schreiber Mentored... 

Q&A with OCRF Grantee John Weroha, MD, PhD

Q&A with John Weroha, MD, PhD 2014 Liz Tilberis Early Career Award Mayo Clinic               Were you always in interested in science?  By the time I was in high school I knew I wanted to have a career in biology, but I think my interest actually started earlier. ...