Research News

Avastin and Chemo for Platinum-Resistant Ovarian Cancer Increases Progression Free Survival

(March 20, 2014) A group of French researchers conducted a randomized, phase III trial (called AURELIA) combining bevacizumab (Avastin) with chemotherapy in platinum-resistant ovarian cancer.  The results of the trial, which enrolled 361 patients, were published in the Journal of Clinical Oncology. The... 

Weekly Carboplatin Plus Paclitaxel Improves Quality of Life

(March 14, 2014)  A large European clinical trial showed that carboplatin plus paclitaxel once a week (versus every three weeks) can be an effective front-line treatment for women with advanced ovarian cancer. The results of the study were published in the medical journal The Lancet. Carboplatin plus... 

OCRF Research Shows Glycans Can Identify Ovarian Cancer

Gary Leiserowitz, MD OCRF-funded research at UC Davis have verified that glycans (sugars attached to proteins) can be used to identify ovarian cancer. The study was published online in the journal Cancer Epidemiology, Biomarkers & Prevention. “This is one of many papers we’ve done to see if... 

Study Shows BRCA1 Mutation Carriers Should Remove Ovaries by Age 35

The findings of a large international study published in the Journal of Clinical Oncology suggest for the first time that women with BRCA1 mutations should have preventive ovarian surgery (prophylactic oophorectomy) by age 35. The report studied nearly 5,800 women with specific genetic mutations called... 

High-dose Vitamin C Helps Ovarian Cancer Patients

(February 21, 2014) Scientists at the University of Kansas Medical Center have determined that high doses of vitamin C, administered intravenously with traditional chemotherapy, helped kill cancer cells while reducing the toxic effects of chemotherapy for some cancer patients. By evaluating the therapy... 

Regular Aspirin Use May Reduce Ovarian Cancer Risk

(February 10, 2014) Women who take aspirin daily may reduce their risk of ovarian cancer by 20 percent, according to a study by scientists at the National Cancer Institute (NCI).  However, further research is needed before clinical recommendations can be made. The study, which was conducted as part... 

Study Shows 1 in 5 Women with Ovarian Cancer has Inherited Predisposition

(January 31, 2014)  A new study conservatively estimates that one in five women with ovarian cancer has inherited genetic mutations that increase the risk of the disease, according to research at Washington University School of Medicine in St. Louis.  Most women in the study would have been unaware... 

OCRF Research Finds New Factor in Ovarian Cancer Development

Yin Wang, PhD (Mayo Clinic)   (January 30, 2014)  OCRF grantee Yin Wang, PhD, led research which found that PKC iota signaling plays an important role in ovarian cancer development. The research, which was published in Molecular Cancer Research, also found that Auranofin,  a small molecular compound,... 

2014 Ovarian Cancer Statistics

(January 22, 2014) Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the National Cancer... 

OCRF Research Identifies Biomarker that May Predict Treatment Response

Analisa DiFeo, PhD (January 13, 2014) Researchers at Case Western Reserve University, led by OCRF grantee Analisa DiFeo, PhD have identified a microRNA biomarker that shows promise in predicting treatment response in the most common form of ovarian cancer – a finding that has the potential to improve...