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Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


OCRF Research Shows ARID1A is Tumor Suppressor Gene

Bin Guan, PhD

Bin Guan, PhD

(July 8, 2014) Frequent mutations in the ARID1A gene have been previously discovered in ovarian endometrioid and clear-cell cancers.  Now research supported by OCRF has provided direct evidence that it is an authentic tumor suppressor gene using a mouse model.  OCRF Ann Schreiber Mentored Investigator grantee Bin Guan, PhD is first author, and OCRF Scientific Advisory Committee Member Ie-Ming Shih, MD, PhD is senior author of a research paper on this topic which is published this month in the Journal of the National Cancer Institute. 

In this study, researchers genetically-modified mice to delete the ARID1A gene, and another tumor suppressor gene, PTEN, from ovarian surface epithelial cells.  These mice then went on to develop ovarian endometrioid or undifferentiated cancers, which resemble human diseases under microscope and by molecular profiling. This study paves new ways to understand the tumorigenesis of ovarian endometrioid cancer and could be essential for pre-clinical studies of novel therapeutics for tumors with ARID1A mutations.

Click here to read the abstract.