2005 Ann Schreiber Grant Recipient – Jason Wilken
Jason Wilken, Ph.D.
Making An Antibody Treatment for Breast Cancer Work for Ovarian Cancer
Traditional chemotherapeutic drugs are effective in destroying ovarian cancer tumors, but these drugs often damage health tissues, resulting in severe side effects. Recently, drugs based on antibodies have been developed that have fewer side effects. One such antibody is Herceptin (by Genentech, Inc.), which is now used clinically for breast cancer. Despite Herceptin’s success in breast cancer treatment, it is ineffective in ovarian cancer. Dr. Wilken hypothesizes that ovarian cancer cells produce a growth factor called heregulin that makes the cells resistant to Herceptin. In his project, Dr. Wilken will attempt to inhibit heregulin activity to make the ovarian cancer cells susceptible to Herceptin. His findings may lead to clinical testing of a new combination therapy for ovarian cancer.
The five-year survival rate for ovarian cancer has increased by only 8% in the last 30 years.
We are at a critical crossroads for supporting research into unlocking the mysteries of ovarian cancer. You can make a difference by supporting the research of the Ovarian Cancer Research Fund.
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