OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!

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2006 Ann Schreiber Grant Recipient – Aliza Leiser

Aliza Leiser, M.D.
Yale University
Clinical Implications of the TLR-4MYD88 Pathway in EOC

Project Summary

The combination of paclitaxel and carboplatin is the most commonly utilized combination chemotherapy in the treatment of primary epithelial ovarian cancers. However, approximately 15 percent of patients do not respond to this combination and their disease will progress during or shortly after the completion of chemotherapy. The general dogma is that those who fail therapy are platinum resistant. Dr. Leiser has identified a molecule in ovarian cancer cells, called MyD88, that seems, however, to confer resistance to paclitaxel. In her project, she plans to study how MyD88 induces resistance to paclitaxel in animal models. Findings could lead to the use someday of alternative drugs for this subgroup of patients who are resistant to paclitaxel and have activated MyD88.