OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!

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2007 Ann Schreiber Grant Recipient – Hong Zhang

Hong Zhang, Ph.D.
Fox Chase Cancer Center
Novel Animal Model to Test Drugs Against Ovarian Cancer

Project Summary

The goal of Dr. Zhang’s research is to validate a mouse model of ovarian cancer to be used to screen new drugs to fight ovarian cancer. His model uses state-of-the-art molecular imaging: Ovarian tumors growing inside the animals ‘glow’ when a specific chemical substrate is injected and the intensity of the glow can be measured to monitor the cancer progression in live animals and evaluate the efficacy of various therapeutic regimens. The first drug to be tested is dasatinib, designed by scientist to bind and inhibit SRC, a protein which has abnormal activity in ovarian cancer. High levels of SRC in ovarian cancer makes cells grow in an uncontrolled way. Dr. Zhang hopes dasatinib will be effective in treating ovarian cancer in his unique animal model of the disease. If so, the model could someday be used to design other treatments against ovarian cancer.