OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2007 Ann Schreiber Grant Recipient – Kuang-Hung-Cheng

Kuang-Hung Cheng, PhD
Brigham and Women’s Hospital
Animal Model to Study Ovarian Cancer Stem Cells

Project Summary

The high rate of therapeutic failure and tumor relapse currently seen in ovarian cancer could result from ineffective targeting of ovarian cancer stem cells. Ovarian cancer stem cells are a population of self-generating cells that are believed to be resistant to chemotherapy. Dr. Cheng is using a mouse model his laboratory developed, called the K-ras+/Pten(-) ovarian cancer model, that mirrors the disease process, precursor lesions and clinical behavior of the human disease with great accuracy. Using this model, he is hoping to isolate ovarian cancer stem cells to understand their role in resistance to drugs and tumor relapse. He also plans to test whether Mullerian Inhibiting Substance and platinum will destroy ovarian cancer stem cells in these mouse models.


Dr. Kuang-Hung Cheng is now an Assistant Professor at the Institute of Biomedical Sciences at National Sun Yat-sen University in Taiwan. His research areas of interest include cancer biology, and cancer stem cells.