2013 Ann Schreiber Grant Recipient – Ronald Lee Chandler
Ronald Lee Chandler, PhD
University of North Carolina, Chapel Hill
A Genetically Relevant Mutant Mouse Model of Epithelial Ovarian Cancer
Ovarian clear-cell and endometrioid carcinomas are among the endometriosis-associated epithelial tumor subtypes with the lowest survival rate. Many of these tumors harbor mutations in ARID1A, an essential protein subunit within the SWI/SNF chromatin-remodeling complex. The goals of this research are to improve our understanding of the functional impact of ARID1A mutations in the cellular and molecular events leading to ovarian cancer through the use of genetically engineered mouse ovarian tumor models. These models will not only further our understanding of the causal relationship that exists between endometriosis and ovarian cancer, but also provide clinicians with a genetically relevant “test bed” for future preclinical drug testing.
Ronald Chandler, Ph.D. is currently a postdoctoral fellow in the Department of Genetics at the University of North Carolina at Chapel Hill. Dr. Chandler obtained a Bachelor of Science degree in Biology and Chemistry from Tennessee Technological University (Cookeville, TN) and Doctor of Philosophy in Molecular Physiology and Biophysics from Vanderbilt University (Nashville, TN). His Ph.D. thesis research focused on Bone Morphogenetic Protein 2 (BMP2) transcriptional regulation and function in osteoblast progenitors. His postdoctoral research in the Laboratory of Dr. Terry Magnuson involves mechanistic structure-function studies on the role of ARID1A within the SWI/SNF chromatin-remodeling complex using the mouse as a genetic model system. Dr. Chandler’s research interests include the role of chromatin structure and its epigenetic regulation in ovarian tumor suppression and endometriosis as a neoplastic process. He received a prestigious American Cancer Society Postdoctoral Fellowship award in 2009.