OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!

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2002 Individual Investigator Grant Recipient – Honami Naora

Honami Naora, M.D., Ph.D.
MD Anderson Cancer Center
How Cells Migrate in the Drosophila Ovary May Lead to a Better Understanding of Ovarian Cancer Metastasis

Project Summary

Ovarian cancer is thought to arise from cells of the surface epithelium of the ovary. However, most patients are diagnosed when the cancer has already spread beyond the ovaries. Such metastatic disease is rarely cured by current therapies. Therefore, understanding the mechanisms that promote metastasis of ovarian cancer is critical for reducing the mortality and morbidity caused by the disease. Many molecular mechanisms are conserved in humans and in lower organisms such as the fruit fly Drosophila. In the Drosophila ovary, a dynamic process of epithelial cell invasion and migration occurs that is reminiscent of the metastatic behavior of human ovarian cancer cells. This process in Drosophila is controlled, at least in part, by a gene called taiman. The taiman gene is related to a human gene called AIB1 that is amplified in breast and ovarian cancers. Dr. Naora hypothesizes that the AIB1 gene regulates metastasis of human ovarian cancer. Her laboratory will test whether inhibiting AIB1 expression in human ovarian cancer cells stops their migratory, invasive behavior. Also, she will examine whether over-expressing the AIB1 gene in human epithelial cells derived from normal ovaries induces these cells to become invasive and migratory. Her findings could lead to a better understanding of metastasis and possible ways to prevent it.

Bio

Dr. Naora is an Associate Professor, Department of Systems Biology, Division of Cancer Medicine, at the University of Texas MD Anderson Cancer Center, Houston, TX.


This award has been made possible by a generous grant from The Louis and Harold Price Foundation, Inc.