1999 Individual Investigator Grant Recipient – Dineo Khabele
Dineo Khabele, M.D.
Albert Einstein College of Medicine/Montefiore Medical Center
Patterns of Gene Expression in Ovarian Cancer
Dr. Khabele will use microarray-based analysis for the examination of the expression of multiple genes in cell culture specimens from patients with ovarian cancer. Using the method, Dr. Khabele hopes to identify new gene mutations in ovarian cancer and to detect differences in the gene expression among different stages of ovarian cancers, ranging from normal tissue to advanced stages of disease. Microarray analysis may make it also possible to assess prognosis based on the initial study of gene expression of a particular specimen. The findings someday may allow the discovery of new biomarkers for early diagnosis and follow-up, and the assessment of specific genetic sites for intervention and therapy.
Dr. Khabele is the Director, Gynecologic Oncology & Women’s Cancer Research Laboratory at Meharry Medical College, and an Assistant Professor of Obstetrics and Gynecology and of Cancer Biology at Vanderbilt-Ingram Cancer Center.