OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2001 Individual Investigator Grant Recipient – Jingwei, Yu

Jingwei, Yu, Ph.D.
Eleanor Roosevelt Institute
Development of DNA Methylation Based Ovarian Cancer Specific Molecular Markers

Project Summary

DNA methylation, the addition of a methyl group to a cytosine residue, is an important modification of DNA molecules essential for normal human development. This modification is often altered in cancers, including ovarian cancer, and this modification is thought to be part of the cancer process. Dr. Yu’s previous studies suggest that the alteration in DNA methylation occurs at a very early stage of ovarian cancer development in an apparently cancer type-specific fashion. Dr. Yu also has identified several ovarian cancer-specific alterations in DNA methylation. The purpose of this study is to develop ovarian cancer specific biological markers based on these DNA methylation alterations and those to be further identified. Such markers will provide basis for leading to novel strategies for diagnosis and prognosis of ovarian cancer and for further investigation of the mechanism of ovarian cancer development.