OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2003 Individual Investigator Grant Recipient – Robert Lucito

Robert Lucito, Ph.D.
Cold Spring Harbor Laboratory
Gene Copy Number Alterations in Ovarian Cancer

Project Summary

Dr. Lucito aims to use an innovative method, called ROMA, that he developed to look at genetic alterations in the genome of ovarian cancer cells. ROMA identifies mutations in the genome where DNA content has been lost–removing genes vital for stopping cells from dividing–and also identifying regions that have been copied excessively or amplified resulting in many copies of a gene that signal the cell to divide. In his study, he will analyze a range of different tumors so he can determine the evolution of genetic changes as the disease progresses. Primary tumors will be compared to metastatic tissue, and, in some cases, metastatic tissue after chemotherapy. From studying such samples, he hopes to identify biomarker gene regions that will be predictors of tumor aggressiveness, response to treatment, chemotherapy resistance, and survival. Also, the regions identified will be important to further characterize the molecular mechanisms behind epithelial ovarian cancer. By identifying the regions that are lost or amplified he can search these regions for genes important in the control of the cell which normally keeps its growth in check.


Dr. Lucito is an Assistant Professor at the Cold Spring Harbor Laboratory in New York. He received his PhD from NYU in 1993.