OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2005 Individual Investigator Grant Recipient – Jill K. Slack-Davis

Jill K. Slack-Davis, Ph.D.
University of Virginia, Charlottesville
How Ovarian Cancer Cells Might Metastasize

Project Summary

Ovarian cancer metastasis is a complex process involving multiple routes, one of which includes attaching to and invading the mesothelium, a membrane that forms the lining of body cavities, to grow into the tissue on the other side. Very little is known about the mechanisms that regulate ovarian cancer metastasis. The goal of this project is to characterize the response of the mesothelium to invading cancer cells using a cell culture system. The system allows Dr. Slack-Davis to identify and characterize the structural changes of the mesothelial cells and the signaling pathways activated within mesothelial cells that promote their separation to allow passage of the ovarian cancer cells. Understanding the mechanisms that disrupt mesothelial integrity would provide additional sites for therapeutic intervention.