OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2005 Individual Investigator Grant Recipient – Terry A. Van Dyke

Terry A. Van Dyke, Ph.D.
University of North Carolina at Chapel Hill
Developing a Mouse Model of Ovarian Cancer

Project Summary

Disruption in a molecular pathway called pRb has been found in more than half of epithelial ovarian cancers, and correlates with lower survival rate of the patients compared with those with no disruption in the pathway. Dr. Van Dyke has developed a tool to disrupt pRb pathway in mice, called T121, which led to abnormal proliferation of cells and epithelial ovarian cancer. The mouse also has abnormal ascites, tumor spreading to local tissues and to the lung. His work demonstrates that human epithelial cancer can be modeled in mice by expression of T121 in ovaries. However, the conventional transgenic strategy that engineered the mouse did not allow him to breed it for further experimentation. In this project, Dr. Van Dyke hopes to engineer a new mouse that would allow him to further study tumor progression.