OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2007 Individual Investigator Grant Recipient – John Risinger

John Risinger, Ph.D.
Michigan State University
Understanding the Genetics of Metastasis May Help Prevent and Stop It

Project Summary

Unfortunately, most ovarian cancers are first diagnosed as advanced metastatic disease when the potential for a cure is slim. Dr. Risinger’s research is aimed at understanding how some ovarian cancers are able to rapidly spread while others remain confined to the ovary. Understanding the differences in the biology of these cancers is a critical in developing more effective treatments for these cancers. Particularly, Dr. Risinger is focused on the role of a newly identified gene, called OVCAPDC1, because it is highly expressed in late stage cancers but undetectable in the normal ovary, stage 1 ovarian cancer and in other adult tissues. Understanding why a gene is expressed so specifically in metastatic cancer but not in other cases makes it a potential marker for prognosis and diagnosis and for the development of therapies that counteract it.


John Risinger, Ph.D., who began his career as a biologist at NIEHS in 1989, is the new director of Gynecologic Oncology Research at the Michigan State University (MSU) College of Human Medicine community-based program in Grand Rapids, Mich. The MSU program works in conjunction with Spectrum Health and the Van Andel Institute. Risinger will begin his work building a laboratory research team that will eventually move to facilities at the Van Andel Institute.