OCRF & Ovarian Cancer National Alliance are now one strong, united, inspiring voice!
Ovarian Cancer Research Fund (OCRF) and the Ovarian Cancer National Alliance (OCNA) have led the way in advocacy, research and support for patients and their families for over 22 years. As of January 2016, we are pleased to announce we are joining together to form Ovarian Cancer Research Fund Alliance (OCRFA), the largest global organization dedicated to advancing ovarian cancer research while supporting women and their families. Read the exciting news!


2007 Individual Investigator Grant Recipient – Tian-Li Wang

Tian-Li Wang, Ph.D.
Johns Hopkins
How One Biological Pathway Running Amok in Ovarian Cells Contributes to Cancer

Project Summary

The biological functions of cells inside human body depend on the intricate networking of signaling pathways. Aberration of those signaling pathways has been linked to many diseases, including cancer. Dr. Wang’s research has focused on studying one of the pathways, called the “Notch signaling pathway” which has been known to play a critical role in cancer development. Recently, he identified Notch3 gene amplification (or increase in gene copy number) and over-expression of the gene product in ovarian cancer cells and showed that these changes lead ovarian cells to grow beyond control. In his project, Dr. Wang plans to study why Notch3 goes awry in normal ovaries and to further understand how aberrant Notch3 signaling contributes to ovarian cancer. His results should help advance understanding of the biology of ovarian cancer and pave the molecular ground toward a possible therapy that targets Notch3.


Dr. Tian-Li Wang is an Assistant Professor in the Department of Obstetrics and Gynecology at the Johns Hopkins Medical Institution in Baltimore, Maryland.