2008 Liz Tilberis Grant Recipient – Rugang Zhang
Rugang Zhang, PhD
Fox Chase Cancer Center
Exploiting Natural Cell Behavior to Stop Cancer Cell Growth
Cellular senescence, or the process whereby normal cells in the body stop dividing, essentially prevents a cell from growing. In mammalian cells grown in tissue culture, cellular senescence can be triggered either by activation of certain special genes called oncogenes or by inactivation of a tumor suppressor gene. This process is termed oncogene-induced senescence. Overriding oncogene induced senescence is a necessary step during tumor progression. Conversely, reactivation of a tumor suppressor gene induces cellular senescence and associated tumor regression due to activation of the innate immune response. Therefore, driving cancer cells to undergo cellular senescence may represent a novel therapeutic approach to combat cancer. The objective of this study is to determine the role of oncogene induced senescence in suppression of ovarian carcinogenesis and to define the function of a particular tumor suppressor pathway, called p53, in mediating this tumor suppressive process.
Dr. Rugang Zhang is a molecular and cell biologist at Fox Chase Cancer Center. His laboratory focuses on understanding the basis of ovarian cancer initiation and progression, with the hope to find new biological “markers” that can be used to detect early signs of the disease and ultimately develop new therapeutics for the cancer. Dr. Zhang received his Ph.D. from Chinese Academy of Science, Institute of Biochemistry and Cell Biology, in Shanghai, China.
The five-year survival rate for ovarian cancer has increased by only 8% in the last 30 years.
We are at a critical crossroads for supporting research into unlocking the mysteries of ovarian cancer. You can make a difference by supporting the research of the Ovarian Cancer Research Fund.
Help us find a cure for ovarian cancer. Donate online and make a difference.